The resulting mixture is diluted with water to achieve the desired concentration. Fung 1996, Okan 2007, CFR 1999Ĭolloidal silver proteins are prepared by mixing silver nitrate, sodium hydroxide, and gelatin. Colloidal silver preparations contain silver ion concentrations of about 1 to 6 ppm (5 to 30 mcg) per dose however, methods of production and silver content of marketed products can be highly variable. Okan 2007 ChemistryĬolloidal silver consists of submicroscopic metallic silver particles suspended in a colloid base. The basic premise is the use of electricity to reduce silver rods to the ionic form and suspend them in a liquid solution. Colloidal silver preparations were formerly included in pharmaceutical texts (ie, prior to 1975) however, in 1999, the FDA ruled that colloidal silver or silver salts for internal or external use are "not generally recognized as safe and effective and are misbranded." CFR 1999Ĭolloidal silver generators are commercially available, and instructional videos demonstrating how to manufacture colloidal silver products at home are available via the internet. Purported uses include cancer, diabetes, arthritis, and many others. Fung 1996, Panacek 2006Ĭolloidal silver products are available as homeopathic remedies and dietary supplements. Fung 1996 Antibacterial activity of silver, reportedly described in ancient Greek texts, has resulted in widespread applications such as in prostheses, catheters, dental materials and textile fabrics, and in the management of skin and other infections. Silver arsphenamine was used for treating syphilis. Franco-Molina 2010, CFR 1999 Historyĭating from the Middle Ages, silver as the nitrate form ("lunar caustic") was used for the treatment of nervous disorders and epilepsy. Hadrup 2014 Colloidal silver is a suspension of submicroscopic metallic silver particles in a colloidal base, which results in an overall increased particle surface area. Sliver nanoparticulate suspensions are typically mixtures consisting of silver ions, nanoparticles, subnano-sized particles, and aggregated nanosized or larger nanoparticles. Silver ions are dissociated from different salts and from particulate silver. Sliver is a metallic element (chemical symbol: Ag) with an atomic number of 47 and an atomic mass of 107.868 g/mol. Hematological and neurological toxicities are rare but well documented. ![]() ToxicologyĪrgyria (purple-grey colored skin) is a recognized adverse outcome of exposure to colloidal silver. GI bleeding, seizures, and skin discoloration reported in the literature are primarily due to silver toxicity (see Toxicology). Oral ingestion of silver salts may cause GI irritation. ![]() Insufficient evidence exists to provide dosing recommendations for colloidal silver. ![]() Despite several purported uses, clinical trial data are lacking to recommend use for any indication, and the US Food and Drug Administration (FDA) has ruled that colloidal silver or silver salts for internal or external use are "not generally recognized as safe and effective and are misbranded." Dosing Clinical Overview UseĬolloidal silver has been investigated for use in wound healing and prevention of wound infection. Common Name(s): Argent colloidal, Colloidal silver, Colloidal silver protein, Plata coloidal, Protéine d’argent, Silver colloid
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